Ensights

A Thermal Stability Study of Phosphoramidites Employed in Oligonucleotide Synthesis In the dynamic world of drug design, thermal stability plays a crucial role, often determining the success of innovative treatments. As researchers push the boundaries of medicine, the need for robust and effective RNA- and DNA-based drugs has never been greater. This is where the phosphoramidite method of DNA synthesis shines, but understanding the thermal stability of its components, especially phosphoramidites, is essential. In this blog, we will explore why thermal stability is vital in drug development, delve into a study focused on phosphoramidites, and discuss its implications for the field.

Reducing Holdup Volume in Sterile Filtration

We’re pleased to share that our Hangzhou, China facilityhas successfully completed an audit with the independent supply chain consortium, Rx-360.

Cell banking is the process of collecting, storing, and preserving cells for future use. It holds immense potential in the realm of medicine. From treating debilitating diseases to regenerating damaged tissues, cell banking offers a glimmer of hope for countless individuals. This guide will delve into the steps involved in the protection of these priceless resources.

Have you ever needed to perform a test only to be held up by wait times for a single-use component? Perhaps you just need a small order of tubing or connectors, without everything that comes with a bulk order? We want to help customers get the right quantity of components when they need them. That’s why Entegris is proud to announce a new relationship with Qosina, a leading global supplier of OEM single-use components to the medical and pharmaceutical industries.

The growth of the biomanufacturing industry has created a demand for new and high-performance fluid handling systems and technologies for the management and storage of cell and gene therapy intermediates and gene-based medicines. New modalities come with risks that don’t yet have good solutions.

Powder can be a mess when not delt with properly. Have you ever dropped a bag of flour on the floor after coming home from the store? Cleaning up the mess is terrible (speaking from experience, don’t add water or you just make glue). Now imagine doing that in a manufacturing suite with powdered media. The powder is literally designed to grow cells, so anything you miss is just a new petri dish that can generate contamination. Plus, there’s the added challenge of having to validate that the room is clean after attending to the spill.

Entegris is delighted to announce our new interactive tool intended to help the life sciences industry better understand how we can support the entire drug manufacturing process. Our growing life sciences portfolio can be overwhelming for customers, and this simple tool helps guide them to finding all the ways we can help. The tool was designed to be versatile and can be shared by our team as part of a sales overview, or you can explore it yourself to quickly learn more about the solutions we offer.

Biopharma manufacturing is an essential part of the healthcare industry, producing lifesaving treatments for patients around the world. Traditional manufacturing methods can have a significant environmental impact driven by stainless steel equipment requiring extensive cleaning and sterilization processes that consume substantial amounts of water and energy in addition to cleaning agents.

Entegris is delighted to announce our collaboration with Agilitech, a pioneering partner to the biotech industry. Agilitech provides highly flexible, scalable, and future-proof single-use technologies for every step of the bioprocess. These include chromatography systems, mixers, and custom-tailored bioprocess controllers that scale from the laboratory to commercial production environments. This makes them a natural fit for the unique needs of life sciences customers.

By: Mike Lamach, Reach-In Sales Leader, FARRAR™ | Trane Technologies The explosion of needs for -80°C through -60°C assets over the past decade has been nothing short of remarkable. Clinical research investments keep expanding while commercial-scale needs continue to transform the landscape.