Science that is transforming lives and enabling the future

Entegris and Kuhner Shaker: Orbital Shaken Bioreactors and Single-Use Bags

All Posts

Entegris and Kuhner Shaker: Orbital Shaken Bioreactors and Single-Use Bags

Entegris is proud to collaborate with Kuhner Shaker in the development of a 2500L single-use bag that could exceed their complex requirements while meeting their production needs at scale. Delivering a reproducible product every time, with the ability for specialized applications across scales is what Entegris does best, and this joint effort is no exception. Kuhner evaluated several bag designs for robustness in their 30-day shaking process that were not able to meet the requirements. The Entegris design not only met the need for 30 days of use but was still going strong over 100 days of continuous use.

Producing a bag that accommodates a large footprint for Kuhner’s bioreactor required specific considerations, including the many different types of filters, end treatments, sensors, tubing diameters as well as final packaging for shipment and sterilization by gamma irradiation. By customizing with the client to meet critical process needs, we collaborated with Kuhner to meet critical process needs.

Our specialties include the following:

  • Both large- and small-scale specialized applications in 50 L, 100 L, 200 L, 500 L, 1000 L, 2500 L
  • Expertise in gamma irradiation and deployment
  • Full quality support including E&L
  • Our environment is core to our values and is factored into all aspects of what we do including life cycle, factory design energy and water used
  • Custom assemblies

Customizable 3D multilayer bioprocess assemblies are ideal for medium to large, single-use biopharmaceutical applications.

  • Process driven design and engineering allows personalized, timely, and knowledgeable attention throughout the collection, design, and ordering process
  • Customizable system design provides design flexibility and allows the system to fit the process rather than the process adapt to the system
  • Standard design library enables quick access to standard products, providing consistently fast development and delivery while minimizing the risk of production delays
  • Rigid bioprocess support containers are available for mixing, processing, storing, and transporting large volumes of solutions

Learn more about how we can help with your custom single-use needs.

Entegris partners with Kuhner AG to provide a large volume, 3D bioreactor bag assembly for their 2500 L bioprocessing shaker. This partnership gives customers a sustainable, flexible, single-use solution.



Related Posts

Billions of Particles, Countless Fibers, and Nine 9's

Here’s a challenge, say the number 9 out loud, nine times. 9, 9, 9, 9, 9, 9, 9, 9, 9.

Tiger Yield: The Importance of FOUP Maintenance

To wrap up the Year of the Tiger (2022), there are still lessons to be learned from the animal kingdom. A tiger out in the open roaming the savannah is at risk of injuries from predators, including human hunters. Wafers left out in the open in a fab are susceptible to damage that can cause dramatic yield drops. The larger the wafer diameter, the greater the risk.

From Penn State to Cold Storage Pioneer: Solving Life Sciences Problems Through a Pattern of Innovation

As the chief technologist for the Life Sciences Division at Trane Technologies, Scott Farrar knows a thing or two about ultra-low temperature control for the life sciences industry, perhaps drawing inspiration from his days at Penn State University enjoying peach ice cream. Scott’s biggest inspiration, however, was his entrepreneurial dad who started a solar equipment company, teaching Scott from a young age the importance of sciences, technology, engineering, and mathematics (STEM) education and solving problems. Scott carried those tools with him, and upon completing his formal education, went to work for a pharmaceutical manufacturing company in research and development, specializing in low-temp freezers and incubators as well as heat-momentum and mass-transfer-type processes for the pharmaceutical industry. His exposure to dilemmas and investigative approach is what drove him to create better customer experiences.